The closest airport to Marzamemi is Comiso Airport, about 80 km inland from southern Sicily, but Catania Airport is recommended: it's only 20 km further away but offers better connections for both car and public transportation. From Catania Airport, Marzamemi can be reached by car in just over an hour; if you prefer public transportation, you can take a direct bus that will get you there in two hours. There are no buses to Marzamemi from Comiso Airport. Direct buses to Marzamemi also depart from all the major towns in eastern Sicily, including Syracuse, Taormina, Avola, Giardini Naxos, and Noto.